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Cobimetinib

Qauv: Nqe lus piav qhia: Cobimetinib (lub npe hu ua Cotellic) yog MEK inhibitor tsim los ntawm Exelixis thiab Genentech. Nws yog siv nrog vemurafenib, ib BRAF inhibitor, los kho cov kab mob melanoma. Thaum lub Kaum Ib Hlis 2015, US Food and Drug Administration tau tso cai cobimetinib rau kev tsis sib haum los yog ...

  • Nta & Specification

    KHOOM NPE

    Cobimetinib

    CAS Naj Npawb:

    934660-93-2

    Synonyms

    [3,4-Sib-2 - [(2-fluoro-4-iodophenyl) amino] phenyl] [3-hydroxy-3- (2S) -2-piperidinyl-1-azetidinyl] methanone

    GDC 0973; XL 518;

    Mis:

    C21H21F3IN3O2

    Molecular phaus:

    531.31000

    PSA:

    64.60000

    LogP:

    4.12080

    Qauv :
    图片 5.png

    Kev piav qhia :

    Cobimetinib (lub npe hu ua Cotellic) yog MEK inhibitor tsim los ntawm Exelixis thiab Genentech. Nws yog siv nrog vemurafenib, ib BRAF inhibitor, los kho cov kab mob melanoma. Thaum lub Kaum Ib Hlis 2015, US Food and Drug Administration tau txais kev tso cai cobimetinib rau kev tsis sib haum lossis metastatic melanoma nrog BRAF V600E lossis V600K hloov, nrog vemurafenib (Zelboraf). Cobimetinib tsis tau qhia rau cov neeg mob uas muaj hom tawv nqaij BRAF plean.
    Cobimetinib ua ke nrog vemurafenib yog tshaj tawm ntawm $ 17,600 tauj ib hlis, lossis txog $ 211,000 rau ib xyoo. Ib qho kev sib tw ua kev sib tw, siv dabrafenib nrog rau trametinib, kuj tau kev pom zoo los ntawm FDA, thiab qhia txog tus nqi $ 15,300 txhua hli, lossis $ 183,600 tauj ib xyoos.
    Peb yuav muab cov khoom no nrog purity 99%.


    Qhov kev kuaj sim ntawm COA

    ProductName: C o bimetinib

    Ua li cas:   934660-93-2

    Batch No .: 20171012

    Hnub tim MFG: Oct. 12.2017

    Tsom xam Cov Hnub Tim: Lub Kaum Ob Hlis Ntuj 2015

     

     

     

    Tshawb Xyuas Yam

    Quantity Standard

    Kev Tshawb Pom Tawm

    Tsos

    Dawb mus rau lub teeb daj

    Dawb hmoov

    Qhia txog

    Zoo

    Conforms

    Purity

    98%

    99.40%

    Tib impurity

    0.20%

    0.33%

    Residual hnyav

    0.50%

    0.30%

    EE tus nqi

    99%

    99.82%

    Xaus

    Ua raws li kev ua lag luam qauv


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