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Fostemsavir

Qauv: Nqe lus piav qhia: Fostemsavir (BMS-663068) yog ib qho kev sim kab mob HIV nkag inhibitor thiab ua ntej ntawm cov tshuaj temsavir (BMS-626529). Nws yog nyob hauv kev txhim kho los ntawm Bristol-Myers Squibb siv rau kev kho tus kab mob HIV. Los ntawm blocking lub gp120 receptor ntawm tus kab mob, nws tiv thaiv thawj kab mob ...

  • Nta & Specification

    P NPE NPE

    Fostemsavir

    CAS Naj Npawb:

    864953-29-7

    Qhia tawm

    1-benzoyl-4- [2- [4-methoxy-7- (3-methyl-1H-1,2,4-triazol-1-yl) -1- [(phosphonooxy) methyl] -1H-pyrrolo [2 , 3-c] pyridin-3-yl] -1,2-dioxoethyl] -piperazine;

    [3- [2- (4-benzoylpiperazin-1-yl) -2-oxoacetyl] -4-methoxy-7- (3-methyl-1,2,4-triazol-1-yl) pyrrolo [2,3- c] pyridin-1-yl] methyl dihydrogen phosphate

    UNII-97IQ273H4L;

    CS-1059;

    Mis :

    C25H26N7O8P

    Molecular phaus :

    583.49000

    PSA:

    192.02000

    LogP:

    1.04390

    Qauv :

    图片 1.png

    Kev piav qhia :

    Fostemsavir (BMS-663068) yog ib qho kev sim kab mob HIV nkag hauvhibitor thiab ib qho khoom ua ntej ntawm temsavir (BMS-626529). Nws yog nyob hauv kev txhim kho los ntawm Bristol-Myers Squibb siv rau kev kho tus kab mob HIV. Los ntawm thaiv lub gp120 receptor ntawm tus kab mob, nws tsis pub thawj tus kab mob kis mus rau lub party CD4 + T cell thiab nkag mus rau hauv lub cev tsis muaj zog; nws txoj kev nqis tes ua yog thawj zaug rau cov tshuaj HIV. Vim hais tias nws lub hom phiaj ntawm cov kab mob khaub thuas, nws muaj kev cog lus rau cov tib neeg muaj tus kab mob uas ua rau cov tshuaj HIV tsis muaj zog. Txij li thaum gp120 yog ib qhov chaw tiv thaiv kab mob ntawm cov kab mob, cov tshuaj no tsis pom zoo los txhawb kev tiv thaiv rau nws tus kheej ntawm kev ua kab mob CD4-ywj siab.
    Peb tuaj yeem muab qhov kev tsim tawm nrog purity 99%.

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