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Sapacitabine

Tus qauv: Nqe lus piav qhia: Sapacitabine yog ib txoj kev tshawb fawb txog kev siv tshuaj tua kab mob. Sapacitabine yog ib qho ncauj nucleoside analog prodrug uas ua los ntawm kev sib xyaw dual mechanism. Cov compound cuam tshuam nrog DNA synthesis los ua ib qho tawg ntoos DNA lov thiab induces ntes ntawm lub ...

  • Nta & Specification

    P NPE NPE

    Sapacitabine

    CAS Naj Npawb:

    151823-14-2

    Qhia tawm

    N- [1 - [(2R, 3S, 4S, 5R) -3-Cyano-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -2-oxopyrimidin-4-yl] hexadecanamide

    CS-682

    Mis :

    C26H42N4O5

    Molecular phaus :

    490.63500

    PSA:

    137.47000

    LogP:

    4.12648

    Qauv :

    图片 9.png

    Kev piav qhia :
    Sapacitabine yog ib txoj kev tshawb fawb txog kev siv tshuaj tua kab mob.
    Sapacitabine yog ib qho ncauj nucleoside analog prodrug uas ua los ntawm kev sib xyaw dual mechanism. Cov compound cuam tshuam nrog DNA synthesis los ntawm ua ib qho tawg ntais DNA zom thiab induces ntes ntawm lub cell division cycle ntawm G2 theem.
    Ob leeg sapacitabine thiab nws cov metabolite loj, CNDAC, tau qhia tias muaj zog tiv thaiv qog nqaij hlav hauv ob qho tib si ntshav thiab khoom hlav hauv kev tshawb xyuas kev tshawb fawb. Nyob rau hauv ib daim siab metastatic nas qauv, sapacitabine tau pom tias yog superior gemcitabine (Gemzar; Lilly) los sis 5-FU, ob lub ntsiab siv cov nucleoside analogs, nyob rau lub sijhawm pib thiab kev loj hlob ntawm daim siab metastasis.

    Ceev: 1.21g / cm3
    Refractive Index 1.574
    Purity: 98%

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